Mechanisms of immunopathology in murine models of central nervous system demyelinating disease.
نویسندگان
چکیده
Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reported to play important roles in myelin destruction. Numerous murine demyelinating models, both virus-induced and/or autoimmune, are available, which reflect the clinical and pathological variability seen in human disease. This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models.
منابع مشابه
Demyelinating Disease Models of Central Nervous System Mechanisms of Immunopathology in Murine
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ورودعنوان ژورنال:
- Journal of immunology
دوره 176 6 شماره
صفحات -
تاریخ انتشار 2006